This page on Scientific Projects aims to provide information on my research profile. I share my time 50/50 between clinical work and research/teaching. Most of my patients have sarcomas (bone- and soft-tissue). I am part of the multidisciplinary sarcoma-group at our Institution. As an oncologist, I am involved in both the radiotherapy and chemotherapy given to these patients. Furthermore, I give radiotherapy to patients with skeletal metastases from other cancers. During the last years, I have been increasingly involved in the use of bone-seeking radiopharmaceuticals in patients with prostate cancer.
My main interest is the tumorbiology of primary and metastatic bone cancers – ranging from basic science aspects in cell biology, radiobiology, microdosimetry and immunology, via the translational phase of new drug development and the prognostic impact of micrometastasis to clinical trials.
- Sarcoma clinical trials
- External beam radiotherapy of skeletal metastases
- Bone-seeking radionuclide therapy
- Vitamin D, skeletal homeostasis and cancer prognosis
- Micrometastasis – characterisation and prognostic impact
- New drug development
- Studies on the pathophysiological barriers to therapeutic macromolecules
- Biologically adapted radiation therapy
- Radiobiology and Microdosimetry
- Monoclonal antibodies
- The theses of people where I have served as academic supervisor are displayed